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Anti-MALT1 Mouse Monoclonal Antibody (Purified) [clone: MT1/410]

Fornitore: Biotium
BNUB0410-500 BNUB0410-100
BNUB0410-500EA 511 EUR
BNUB0410-500 BNUB0410-100
Anti-MALT1 Mouse Monoclonal Antibody (Purified) [clone: MT1/410]
Anticorpi
Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.

Type: Primary
Antigen: MALT1
Clonality: Monoclonal
Clone: MT1/410
Conjugation: Purified
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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