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Anti-CD33 Mouse Monoclonal Antibody (CF640R) [clone: C33/69]

Fornitore: Biotium
BNC400069-500 BNC400069-100
BNC400069-500EA 560 EUR
BNC400069-500 BNC400069-100
Anti-CD33 Mouse Monoclonal Antibody (CF640R) [clone: C33/69]
Anticorpi
Recognizes a 67 kDa glycoprotein, which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

Type: Primary
Antigen: CD33
Clonality: Monoclonal
Clone: C33/69
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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