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5-Fluoro-2'-deoxyuridine (floxuridine) ≥98%, white powder

Fornitore: MP Biomedicals
Pericolo

Synonyms: 5-Fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione, 5-Fluoro-2'-deoxyuridine, Floxuridine

0210555110 0210555125 0210555180
ICNA0210555110EA 35.4 EUR
ICNA0210555110 ICNA0210555125 ICNA0210555180
5-Fluoro-2'-deoxyuridine (floxuridine) ≥98%, white powder
5-Fluoro-2'-deoxyuridine (floxuridine)

5-Fluorodeoxyuridine is an antineoplastic agent, which acts as an anti-metabolite. When administrated by rapid injection it acts as flurouracil, but when infused slowly, usually intra-arterially, it is converted to active F-dUMP, which leads to enhanced inhibition of DNA synthesis. It inhibits DNA synthesis by blocking thymidylic acid synthetase.


  • Extinction Coefficient (E1%): EmM = 8.91 (0.1 M phosphate buffer, pH 6.0) (Lit.)
  • Optical Rotation: +37 ° (10 mg/mL in water at 25 °C) (Lit.)
  • pKa:7.6 (Lit.)


5-Fluorodeoxyuridine can be used to target thymidylate synthetase in cancer chemotherapy. Experimental anticancer agent shown to have activity against a variety of malignant neoplasms, including mouse mammary tumors and colorectal carcinomas.
Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase. Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.


Soluble in water (clear, colourless solution); DMF.


Attenzione: Research Use Only (RUO).

Formula: C₉H₁₁FN₂O₅
Peso molecolare: 246,19 g/mol
Punto di fusione: 142…155 °C
Temperatura di stoccaggio: Congelamento
MDL Number: MFCD00006530
CAS Number: 50-91-9
UN: 2811
ADR: 6.1,III

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Risultati del test di specificazione

Identity Test Passes
Purity ≥98%
FTIR Conforms to Standard
Melting Point 142 - 155 °C
UV/VIS: l max (water) 266 - 270 nm

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