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Ketoconazole ≥98%, white powder

Fornitore: MP Biomedicals
Pericolo

Synonyms: (+/-)-cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine

0215915850 0215915880 0215915890
ICNA0215915850EA 75 EUR
ICNA0215915850 ICNA0215915880 ICNA0215915890
Ketoconazole ≥98%, white powder
Ketoconazole

Ketoconazole is an antifungal agent; Cytochrome P450 inhibitor and demonstrates anti-psoriatic activity. A liver cytochrome responsible for the metabolism of many drug substrates in humans.


Ketoconazole is a broad spectrum antifungal agent used to treat candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. It is a CYP3A4 inhibitor. It is used to identify p-glycoprotein/CYP3A-limited bioavailability in the monkey model, to study interleukin 1 mediated antitumor effects, and drug interactions in vivo.


Ketoconazole as an Antifungal agent, interacts with 14-α demethylase, a cytochrome P-450 enzyme that is necessary for the conversion of lanosterol to ergosterol. This interaction inhibits ergosterol synthesis and results in increased fungal cellular permeability. Other possible mechanisms of action are the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole inhibits the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone .


Soluble in DMSO or chloroform.

Formula: C₂₆H₂₈Cl₂N₄O₄
Peso molecolare: 531,43 g/mol
Temperatura di stoccaggio: Ambiente
MDL Number: MFCD00058579
CAS Number: 65277-42-1
UN: 2811
ADR: 6.1,III

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Risultati del test di specificazione

Identity Test Passes
Purity ≥98%
FTIR Conforms to Standard
Melting Point 145 - 152 °C

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