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Gossypol acetic acid, in polvere

Fornitore: MP Biomedicals

0219521180 0219521183 0219521125
ICNA0219521180EA 97.4 EUR
ICNA0219521180 ICNA0219521183 ICNA0219521125
Gossypol acetic acid, in polvere
Gossypol acetic acid

Soluble in acetone and in methanol (5 mg/ml) yielding a clear to very slightly hazy, yellow to amber solution. Gossypol is insoluble in water, very slightly soluble in petroleum ether and soluble in ethanol, ether, chloroform and DMF. It is freely soluble (with slow decomposition) in dilute aqueous solutions of ammonia and sodium carbonate.


In a study on the apoptotic effect of gossypol on human lymphocytes, gossypol was used at 20-50 mM to induce apoptosis in human lymphocytes without causing necrosis through cytotoxic effects. The combined use of steroid hormones (methyl testosterone and ethinyl estradiol) and gossypol (low dose) in an antifertility study in rats showed that the steroid hormone made the procedure of spermatogenesis slower and low dose gossypol caused all sperm to lose their activity in the epididymis. Both affect the process of spermatogenesis from different endpoints and successfully induce infertility in the short term. A low dose of gossypol not only executes antifertility function in the epididymis, but also affects the quality of spermatozoa production in testis by impacting the procedures of both acrosomal formation and spermatozoa elongation. This assists in maintaining long term infertility. Gossypol, as a PAF antagonist/inhibitor, markedly inhibited the contractile responses of guinea-pig lung parenchyma strips stimulated with leukotriene B4, leukotriene D4, and PAF-acether. It was suggested that the inhibition of the myotropic activity of the lung parenchyma by gossypol is due to interactions with the formation of cyclooxygenase products within the guinea-pig lung. Inhibits the autolytic conversion of pepsinogen to pepsin.


The toxicity of gossypol is shown against the reproductive system, heart, liver, and membranes. The compound exhibits both pro- and anti-oxidant behavior. Electron transfer (ET) functionalities, present in gossypol and its metabolites, comprise conjugated dicarbonyl, a quinone derivative, Schiff bases, and metal complexes. The parent possesses a reduction potential favorable for in vivo ET. Considerable evidence points to oxidative stress, formation of a reactive oxygen species, and DNA scission, characteristics of redox cycling by ET in Biosystems, as mechanism of action for gossypol. Reported to inhibit the autolytic conversion of pepsinogen to pepsin.

Formula: C₃₂H₃₄O₁₀
MDL Number: MFCD00058385
CAS Number: 12542-36-8

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