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Cytosine-β-D-arabinofuranoside hydrochloride, in polvere

Fornitore: MP Biomedicals
Attenzione

Synonyms: Arabinosylcytosine hydrochloride, Cytarabine HCI, Cytarabine HCl, 4-Amino-1-((2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one hydrochloride, 1-(β-D-Arabinofuranosyl)cytosine HCl

0210007105 02100071.1 02100071.5 0210007101
ICNA0210007105EA 1015 EUR
ICNA0210007105 ICNA02100071.1 ICNA02100071.5 ICNA0210007101
Cytosine-β-D-arabinofuranoside hydrochloride, in polvere
Cytosine-beta-D-arabinofuranoside hydrochloride

Soluble in water (50 mg/ml - clear, colourless solution).


Cytosine β-D-arabinofuranoside hydrochloride is an anti-leukemic agent. It results in DNA fragmentation and inhibition of replication. In addition this compound does not have any effects on RNA synthesis. Cytosine β-D-arabinofuranoside hydrochloride can function as a ligand which shows strong affinity and selectivity for the Translocator protein (TSPO). Studies suggest that cytosine β-D-arabinofuranoside hydrochloride can down-regulate deoxycytidine kinase in acute myeloid leukemia murine cell lines which inhibits the phosphorylation of several deoxyribonucleosides. Furthermore, cytosine β-D-arabinofuranoside hydrochloride can be inhibited in myeloid leukemic cells via suppression of ENT1 promoter activity, responsible for transporting cytosine β-D-arabinofuranoside into the cell.


Cytosine β-D-arabinofuranoside hydrochloride is a selective inhibitor of DNA synthesis that does not affect RNA synthesis in mammalian cells. It is used as an antineoplastic and antiviral agent.


Ara-C an anti-leukemia agent is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. It does not inhibit RNA synthesis.

Formula: C₉H₁₄ClN₃O₅
Peso molecolare: 279,677 g/mol
MDL Number: MFCD00012839
CAS Number: 69-74-9

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