Stampa…

Farnesyl thiosalicylic acid ≥96%

Fornitore: Cayman Chemical

Synonyms: Salirasib, FTS

10010501-10 10010501-25 10010501-5
CAYM10010501-10EA 157 EUR
CAYM10010501-10 CAYM10010501-25 CAYM10010501-5
Farnesyl thiosalicylic acid ≥96%
Farnesyl thiosalicylic acid

Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid (FTS) is an inhibitor of Ras-mediated signaling that functions by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation.


FTS inhibits the growth of human Ha-ras-transformed Rat1 fibroblasts with an IC50 value of 7.5 µM.It does not inhibit Ras farnesylation in vitro and although FTS does inhibit prenylated protein methyltransferase (PPMTase) in cell-free systems with a Ki value of 2.6 µM, it is relatively ineffective at inhibiting methylation in whole cells.Treatment of chow-fed ApoE-deficient mice with 5 mg/kg FTS three times per week for six weeks reduces early atherosclerotic lesion development by 52% compared to controls.

Formula: C₂₂H₃₀O₂S
Peso molecolare: 358,54 g/mol
MDL Number: MFCD00467723
CAS Number: 162520-00-5

Visualizza i codici

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Informazioni About VWR