Hai cercato: Trimethoprim

Fornitore: Apollo Scientific

Descrizione: This antibiotic is a dihydrofolate reductase inhibitor. It inhibits the conversion of bacterial dihydrofolic acid to tetrahydrofolic acid which is necessary for the synthesis of amino acids, etc. and ultimately DNA synthesis.

Certificati

Fornitore: TCI

Descrizione: Trimethoprim ≥98.0% (by HPLC, titration analysis)

Fornitore: Thermo Fisher Scientific

Descrizione: Trimethoprim 98%

MSDS

Fornitore: Thermo Fisher Scientific

Descrizione: Trimethoprim

MSDS Certificati

Fornitore: MP Biomedicals

Descrizione: Trimethoprim is an antibacterial agent; a specific inhibitor of formylation; a dihydrofolate reductase inhibitor.
Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.
The combination of Trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.