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Descrizione: Succinimidyl 4-(N-maleimidomethyl) cyclohexane-1-carboxylate Heterobifunctional Cross Linkers.
Codice catalogo: BC20
UOM: 1 * 100 mg
Codice articolo fornitore: BC20
Codice articolo locale: GENOBC20
Fornitore: G-Biosciences


Descrizione: SMCC (N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate) ≥98.0% (by HPLC)
Codice catalogo: TCIAS0853-100MG
UOM: 1 * 100 mg
Codice articolo fornitore: S0853-100MG
Codice articolo locale: TCIAS0853-100MG
Fornitore: TCI


Descrizione: Primary amine and Sulphhydryl reactive, Enzyme antibody conjugation.
Codice catalogo: APOSBICL206-25MG
UOM: 1 * 25 mg
Codice articolo fornitore: BICL206-25MG
Codice articolo locale: APOSBICL206-25MG
Fornitore: Apollo Scientific


Descrizione: SMCC is a non-cleavable and membrane permeable crosslinker with a spacer arm of 8.3 Å. It contains an amine-reactive succinimidyl ester (SE) and a sulfhydryl-reactive maleimide group. NHS esters react with primary amines at pH 7 to 9 to form stable amide bonds. Maleimides react with sulfhydryl groups at pH 6.5 to 7.5 to form stable thioether bonds. The SE group of SMCC is reacted with lysine residues on the carrier protein, converting them to reactive maleimides. SMCC is a reagent that is widely used for generating stable maleimide-activated carrier proteins that can spontaneously react with sulfhydryls. Alternatively these relatively stable maleimide-activated intermediates may be lyophilized and stored for later conjugation to a hapten.
Codice catalogo: AATB4501
UOM: 1 * 25 mg
Codice articolo fornitore: 4501
Codice articolo locale: AATB4501
Fornitore: AAT BIOQUEST


Descrizione: Thermo Scientific Pierce SMCC is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7–9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5–7.5 to form stable thioether bonds. In aqueous solutions, NHS ester hydrolytic degradation is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group, but will slowly hydrolyze and lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugations with these crosslinkers are usually performed at pH 7.2–7.5, with the NHS ester (amine-targeted) reacted before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.
Codice catalogo: PIERA35394
UOM: 1 * 10 mg
Codice articolo fornitore: A35394
Codice articolo locale: PIERA35394
Fornitore: Thermo Fisher Scientific


Descrizione: Thermo Scientific Pierce SMCC is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7–9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5–7.5 to form stable thioether bonds. In aqueous solutions, NHS ester hydrolytic degradation is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group, but will slowly hydrolyze and lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugations with these crosslinkers are usually performed at pH 7.2–7.5, with the NHS ester (amine-targeted) reacted before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.
Codice catalogo: PIER22360
UOM: 1 * 50 mg
Codice articolo fornitore: 22360
Codice articolo locale: PIER22360
Fornitore: Thermo Fisher Scientific

Descrizione: Heterobifunctional reagent useful for enzyme labeling of antibodies and antibody fragments. Cross-links both a sulfhydryl group and a free amine group. Useful for sequential conjugation to minimize polymerization.
Reacts with primary amines and sulfhydryl groups.
Codice catalogo: 573114-100
UOM: 1 * 100 mg
Codice articolo fornitore: 573114-100
Codice articolo locale: CALB573114-100
Fornitore: Merck Millipore (Calbiochem‎)

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