Hai cercato: Proteine e Peptidi

Fornitore: Shenandoah Biotechnology

Descrizione: IL-21 is a common chain cytokine regulating many cell types of the immune system. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. Plays an important role in the development of humoral immunity through its effects on B cell biology including differentiation, affinity maturation, and memory responses.

New Product

Fornitore: Shenandoah Biotechnology

Descrizione: PDGF-BB (Platelet-derived growth factor) comprises a family of homo or heterodimeric growth factors, including PDGF-AA, PDGF-BB, PDGF-CC, and PDGF-DD. Binds to two different transmembrane tyrosine kinase receptors (PDGFR-alpha and PDFGR-beta). Released from degranulating platelets and plays a role in each stage of wound healing. Stimulates mitogenicity and chemotaxis of neutrophils, macrophages, fibroblasts, and smooth muscle cells to the wound site.

New Product

Codice catalogo: (ENZORLT-300-023)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: RLT-300-023

Codice articolo locale: ENZORLT-300-023

Descrizione: Human Recombinant TGF-beta1 (from CHO cells)

UOM: 1 * 10 µG

New Product Promo

Fornitore: Shenandoah Biotechnology

Descrizione: Interleukin 17A (IL-17A), also known as CTLA-8, is a member of the IL-17 family of proteins. IL-17A is a proinflammatory cytokine that is secreted by activated CD4+ and CD8+ T lymphocytes. IL-17A acts through its receptor, IL-17R, to promote increased cytokine and chemokine secretion. In turn, the cytokines and chemokines mediate the immunoregulatory function of IL-17A by promoting the proliferation, maturation, and chemoattraction of neutrophils to inflammatory sites.  Elevated levels of IL-17A are associated with rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer, and multiple sclerosis.  Human, mouse, and rat IL-17A show activity on mouse cells.  

New Product

Fornitore: Shenandoah Biotechnology

Descrizione: Platelet-derived growth factor (PDGF) is an important regulator of cell growth, proliferation, and angiogenesis. PDGF synthesis is induced by IL-1, IL-6, TNF-α, TGF-β, and EGF signaling. PDGF functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells. PDGF is also stored in the alpha-granules of platelets and is released upon adherence to traumatised tissues. PDGF is a dimeric glycoprotein formed by two A chains (AA), two B chains (BB), or as a heterodimer with an A and a B chain (AB). The PDGF dimer binds the cell surface receptor tyrosine kinases PDGFR-α and PDGFR-β.

New Product

Fornitore: Shenandoah Biotechnology

Descrizione: Vascular endothelial growth factor-A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways. VEGF-A has several alternatively spliced isoforms, with VEGF-165 being the most abundant. The VEGF-165 isoform is a secreted protein that acts on receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell proliferation and angiogenesis.

New Product

Codice catalogo: (SHBTPB-500-18)

Fornitore: Shenandoah Biotechnology

Codice articolo fornitore: PB-500-18

Codice articolo locale: SHBTPB-500-18

Descrizione: IL-2C126S, an immune-regulating cytokine originating from lymphocytes, operates via the IL-2R receptor to trigger the expansion of activated T cells and encourage T cell maturation. IL-2 mediates its action by binding to IL-2 receptors (IL-2R), consisting of either trimeric receptors made of IL-2Rα (CD25), IL-2Rβ (CD122), and IL-2Rγ (γc, CD132) chains or dimeric βγ IL-2Rs.

UOM: 1 * 1 KIT

New Product Promo

Codice catalogo: (SHBTPB-500-17)

Fornitore: Shenandoah Biotechnology

Codice articolo fornitore: PB-500-17

Codice articolo locale: SHBTPB-500-17

Descrizione: Cytokines for human neuronal cell culture. Neural Stem Cells (NSC) are self-renewing cells, of the neural lineage, capable of generating neurons (GABA, dopamine and motor neurons), astrocytes and oligodenrocytes. NSCs are marked by expression of Nestin and can be derived from fetal neural stem cells, adult neural stem cells, embryonic stem cells and adult somatic cells. NSCs are typically expanded and maintained in 2D monolayers or 3D neurosphere cultures containing recombinant EGF and FGF-basic (also called FGF-2 or FGFb). To differentiate NSCs to more specific cell types, the EGF and FGF-basic containing media is often replaced with media containing various cocktails of BDNF, SHH, FGF-8, CNTF, LIF, BMP-4, NT-3, NT-4, PDGFs and other cytokines. Recombinant human EGF and FGF-basic show cross-species reactivity so they are sometimes used in mouse and/or rat cultures.

UOM: 1 * 1 KIT

New Product Promo

Codice catalogo: (SHBTPB-500-12)

Fornitore: Shenandoah Biotechnology

Codice articolo fornitore: PB-500-12

Codice articolo locale: SHBTPB-500-12

Descrizione: Cytokines for polarizing human T cells into Th9 cells. Th9 cells are a unique subset of T helper cells that produce IL-9. An important function of IL-9 producing T cells is fighting inflammation and helminth infections. Th9 cells can be generated from naive CD4+ T cells in culture by culturing them in the presence of IL-4 and TGF-β 1. It also appears that IFNγ and IL-27 can inhibit the generation of Th9 cells.

UOM: 1 * 1 KIT

New Product Promo

Codice catalogo: (SHBTPB-500-11)

Fornitore: Shenandoah Biotechnology

Codice articolo fornitore: PB-500-11

Codice articolo locale: SHBTPB-500-11

Descrizione: Cytokines for polarising human T cells into Th17 cells. T helper 17 cells (Th17) are a distinct type of T cell subset that are thought to be important in immunity against microbes at the epitilial and mucosal interfaces of the body. Disruption of the regular function or balance of Th17 cells is thought to be involved in several autoimmune diseases and/or opportunistic infections. Th17 cells are characterised by their ability to produce IL-17, IL-22 and IL-21. Th17 cells can be cultured from naive CD4+ T cells by culturing them in the presence of anti-CD3 and anti-CD28 stimulation with recombinant IL-6 and recombinant TGF-β 1.

UOM: 1 * 1 KIT

New Product Promo

Fornitore: Thermo Fisher Scientific

Descrizione: Casein sodium salt

MSDS

Codice catalogo: (APOSBITP1794-1MG)

Fornitore: Apollo Scientific

Codice articolo fornitore: BITP1794-1MG

Codice articolo locale: APOSBITP1794-1MG

Descrizione: Recombinant Hepatitis C Virus NS5

UOM: 1 * 1 mg

Promo

Codice catalogo: (APOSBITP1791-1MG)

Fornitore: Apollo Scientific

Codice articolo fornitore: BITP1791-1MG

Codice articolo locale: APOSBITP1791-1MG

Descrizione: Recombinant Hepatitis C Virus NS4 a+b

UOM: 1 * 1 mg

Promo

Codice catalogo: (APOSBITP1840-1MG)

Fornitore: Apollo Scientific

Codice articolo fornitore: BITP1840-1MG

Codice articolo locale: APOSBITP1840-1MG

Descrizione: Recombinant Cytomegalo Virus pP28 (UL99)

UOM: 1 * 1 mg

Promo

Codice catalogo: (APOSBITP1782-1MG)

Fornitore: Apollo Scientific

Codice articolo fornitore: BITP1782-1MG

Codice articolo locale: APOSBITP1782-1MG

Descrizione: Recombinant Hepatitis C Virus NS3, HRP (Horseradish Peroxidase)

UOM: 1 * 1 mg

Promo

Fornitore: TCI

Descrizione: E-64d