Hai cercato: Anticorpi

Codice catalogo: (BOSSBS-12088R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-12088R-A680

Codice articolo locale: BOSSBS-12088R-A680

Descrizione: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC1 (zinc finger, DHHC-type containing 1), also known as ZNF377 (zinc finger protein 377) or C16orf1, is a 485 amino acid multi-pass membrane protein that contains one DHHC-type zinc finger. Expressed in fetal heart, lung and kidney and also present in adult lung and pancreas, ZDHHC1 functions as a palmitoyltransferase that catalyses the conversion of palmitoyl-CoA and protein-cysteine to S-palmitoyl protein and CoA. Like ZDHHC1, ZDHHC5, ZDHHC6, ZDHHC7 and ZDHHC18 each contain one DHHC-type zinc finger through which they convey palmitoyltransferase activity against a broad range of substrates, including H-Ras, SNAP 25 and GABAA R proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1351R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-1351R-A680

Codice articolo locale: BOSSBS-1351R-A680

Descrizione: This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-7525R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-7525R-A555

Codice articolo locale: BOSSBS-7525R-A555

Descrizione: This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9098R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-9098R-A750

Codice articolo locale: BOSSBS-9098R-A750

Descrizione: ANKS3 is a 656 amino acid protein that contain six ANK repeats and one SAM (sterile alpha motif) domain. The gene encoding ANKS3 maps to human chromosome 16. Chromosome 16, which is associated with a variety of genetic disorders, encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterised by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-15338R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-15338R-A680

Codice articolo locale: BOSSBS-15338R-A680

Descrizione: Chromosome 9 consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterised by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. The C9orf68 gene product has been provisionally designated C9orf68 pending further characterisation. There are two isoforms of C9orf68 that are produced as a result of alternative splicing events.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12146R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-12146R-A488

Codice articolo locale: BOSSBS-12146R-A488

Descrizione: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-7714R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-7714R-A680

Codice articolo locale: BOSSBS-7714R-A680

Descrizione: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organisation of stable microtubule binding sites in the outer plate of the kinetochore.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-10153R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-10153R-A647

Codice articolo locale: BOSSBS-10153R-A647

Descrizione: Detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. Found in leukocytes of the myeloid lineage, with the strongest expression observed in granulocytes and no detectable expression in lymphocytes. Expressed in thymic epithelial cells and fibroblasts.Belongs to the SECTM family.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-15227R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-15227R-A647

Codice articolo locale: BOSSBS-15227R-A647

Descrizione: Making up nearly 6% of the human genome, chromosome 6 contains around 1200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf163 gene product has been provisionally designated C6orf163 pending further characterisation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6746R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-6746R-A750

Codice articolo locale: BOSSBS-6746R-A750

Descrizione: TULP2 is a member of a family of tubby-like (TULP) proteins which share a conserved C terminal region of approximately 200 amino acid residues. It is strongly expressed in testis and is expressed in the retina. It is also expressed in cancer cell lines.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13029R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-13029R-A647

Codice articolo locale: BOSSBS-13029R-A647

Descrizione: Dipeptidyl peptidases (DPPs) mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. DPP3 (dipeptidyl-peptidase 3), also known as DPPIII, is a zinc-exopeptidase that belongs to the peptidase M49 family. DPP3 localizes to the cytoplasm and is involved in intracellular protein catabolism. More specifically, DPP3 is an important enzyme involved in the degradation of enkephalins. An increase in the activity of DPP3 is implicated in ovarian and endometrial cancers.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11952R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-11952R-A750

Codice articolo locale: BOSSBS-11952R-A750

Descrizione: The four isoforms of potassium/chloride co-transport channels (KCC) belong to a superfamily of cation-chloride co-transporters involved in cell volume maintenance. Nitric oxide (NO) donors activate KCCs, while inhibitors of the cGMP pathway prevent NO donor activation. The ubiquitously expressed KCC1 contains 12 transmembrane domains with both cytoplasmic N and C terminal domains. KCC2 expression is limited to neuronal tissues by a restrictive element similar to the neuronal-restrictive silencing factor. In neurons, KCC2 expression is correlated with an inhibitory response to GABA, while the absence of KCC2 is necessary for an unusual excitatory response to GABA. Alterations of KCC2 expression in the inferior colliculus of rat brain may be related to seizure susceptibility. Conversely, KCC3 is not suspected to play a major role in epilepsy. The two splice variants of KCC3, KCC3a and KCC3b, are predominantly expressed in brain and kidney, respectively, while KCC4 is expressed in muscle, brain, lung, heart and kidney.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11490R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-11490R-A647

Codice articolo locale: BOSSBS-11490R-A647

Descrizione: A mutation of the DYT1 gene, which codes for TorsinA, has been identified as the cause of one form of autosomal dominantly inherited dystonia. Early-onset torsion dystonia is a movement disorder, characterized by twisting muscle contractures, that begins in childhood. Symptoms are believed to result from altered neuronal communication in the basal ganglia. TorsinA comprises 332 amino acids. TorsinA is widely expressed throughout the mouse central nervous system and is detected in the majority of neurons in nearly all regions. The proteins display cytoplasmic distribution, although in some types of neurons localization is perinuclear. TorsinA often performs chaperone-like functions that assist in the assembly, operation, or dis-assembly of protein complexes. The gene which encodes TorsinA has high homology to three additional mammalian genes and a nematode gene and distal similarity to the family of heat-shock proteins and the Clp protease family. The gene which encodes TorsinA maps to human chromosome 9q34.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-10152R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-10152R-A750

Codice articolo locale: BOSSBS-10152R-A750

Descrizione: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4280R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-4280R-A488

Codice articolo locale: BOSSBS-4280R-A488

Descrizione: This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-8127R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-8127R-A750

Codice articolo locale: BOSSBS-8127R-A750

Descrizione: This gene is located in a region close to the locus of the pseudogene of chemokine (C-C motif) receptor-like 1 on chromosome 6. The specific function of this gene has not yet been determined.

UOM: 1 * 100 µl

Promo