Hai cercato: 4-Iodosalicylic+acid

Codice catalogo: (BOSSBS-3541R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-3541R-CY5

Codice articolo locale: BOSSBS-3541R-CY5

Descrizione: Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11348R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-11348R-CY3

Codice articolo locale: BOSSBS-11348R-CY3

Descrizione: Hippocalcin is a neuron-specific calcium-binding protein found primarily in the plasma membrane of brain and retinal tissue, with increased expression observed in hippocampal pyramidal cells. Through its calcium-dependent signal regulation, hippocalcin can both inhibit rhodopsin kinase and increase phospholipase D2 expression. In order to regulate kinase and phospholipase activity, hippocalcin must bind to the plasma membrane where it can then bind two calcium ions for use in signal regulation. The hippocalcin protein is highly conserved in mouse, rat and human tissue and has a suggested role in neural plasticity and associative memory by contributing to the survival of neurons during aging. The loss of hippocalcin expression is thought to contribute to age-related impairment of post-synaptic functions related to neuronal degradation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3541R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-3541R-CY7

Codice articolo locale: BOSSBS-3541R-CY7

Descrizione: Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0177R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-0177R-A647

Codice articolo locale: BOSSBS-0177R-A647

Descrizione: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S1B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0177R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-0177R-A680

Codice articolo locale: BOSSBS-0177R-A680

Descrizione: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S1B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4999R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-4999R-A555

Codice articolo locale: BOSSBS-4999R-A555

Descrizione: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1449R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-1449R-A350

Codice articolo locale: BOSSBS-1449R-A350

Descrizione: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3872R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-3872R-CY7

Codice articolo locale: BOSSBS-3872R-CY7

Descrizione: Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.

UOM: 1 * 100 µl

Promo

Fornitore: Apollo Scientific

Descrizione: Tyrphostin 1 95%

Codice catalogo: (BOSSBS-3872R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-3872R-A680

Codice articolo locale: BOSSBS-3872R-A680

Descrizione: Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11833R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-11833R-A488

Codice articolo locale: BOSSBS-11833R-A488

Descrizione: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11833R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-11833R-A647

Codice articolo locale: BOSSBS-11833R-A647

Descrizione: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5890R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-5890R-A555

Codice articolo locale: BOSSBS-5890R-A555

Descrizione: Present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5890R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-5890R-A680

Codice articolo locale: BOSSBS-5890R-A680

Descrizione: Present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan.

UOM: 1 * 100 µl

Promo

Fornitore: Cytiva (Formerly Pall Lab)

Descrizione: The disposable Minimate™ TFF capsules, with Omega™ membrane, can perform concentration processes desalting or buffer exchange on the same system with minimal user intervention, and achieves high concentration factors in a single step due to the low hold-up volume of the devices.

Codice catalogo: (BOSSBS-1449R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-1449R-A555

Codice articolo locale: BOSSBS-1449R-A555

Descrizione: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

UOM: 1 * 100 µl

Promo