Hai cercato: Sartorius

Descrizione: Cadherins are calcium-dependent cell-cell adhesion molecules, and protocadherins constitute a subfamily of nonclassic cadherins. Protocadherin beta 13 is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

Codice catalogo: BOSSBS-5828R-A488

UOM: 1 * 100 µl

Codice articolo fornitore: BS-5828R-A488

Codice articolo locale: BOSSBS-5828R-A488

Fornitore: Bioss

Promo

Descrizione: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.

Codice catalogo: BOSSBS-0098R-A350

UOM: 1 * 100 µl

Codice articolo fornitore: BS-0098R-A350

Codice articolo locale: BOSSBS-0098R-A350

Fornitore: Bioss

Promo

Descrizione: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.

Codice catalogo: BOSSBS-0289R-A680

UOM: 1 * 100 µl

Codice articolo fornitore: BS-0289R-A680

Codice articolo locale: BOSSBS-0289R-A680

Fornitore: Bioss

Promo

Descrizione: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro (By similarity).

Codice catalogo: BOSSBS-0217R-A680

UOM: 1 * 100 µl

Codice articolo fornitore: BS-0217R-A680

Codice articolo locale: BOSSBS-0217R-A680

Fornitore: Bioss

Promo

Descrizione: 14-3-3 family protein

Codice catalogo: BOSSBS-2017R-A555

UOM: 1 * 100 µl

Codice articolo fornitore: BS-2017R-A555

Codice articolo locale: BOSSBS-2017R-A555

Fornitore: Bioss

Promo

Descrizione: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.

Codice catalogo: BOSSBS-0216R-A555

UOM: 1 * 100 µl

Codice articolo fornitore: BS-0216R-A555

Codice articolo locale: BOSSBS-0216R-A555

Fornitore: Bioss

Promo

Descrizione: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]

Codice catalogo: BOSSBS-2329R-A555

UOM: 1 * 100 µl

Codice articolo fornitore: BS-2329R-A555

Codice articolo locale: BOSSBS-2329R-A555

Fornitore: Bioss

Promo

Descrizione: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B.

Codice catalogo: BOSSBS-2456R-A350

UOM: 1 * 100 µl

Codice articolo fornitore: BS-2456R-A350

Codice articolo locale: BOSSBS-2456R-A350

Fornitore: Bioss

Promo

Descrizione: Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.

Codice catalogo: BOSSBS-5888R-A555

UOM: 1 * 100 µl

Codice articolo fornitore: BS-5888R-A555

Codice articolo locale: BOSSBS-5888R-A555

Fornitore: Bioss

Promo

Descrizione: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.

Codice catalogo: BOSSBS-0165R-A488

UOM: 1 * 100 µl

Codice articolo fornitore: BS-0165R-A488

Codice articolo locale: BOSSBS-0165R-A488

Fornitore: Bioss

Promo

Descrizione: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalisation and degradation; MMP14 promotes internalisation and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Codice catalogo: BOSSBS-0676R-A680

UOM: 1 * 100 µl

Codice articolo fornitore: BS-0676R-A680

Codice articolo locale: BOSSBS-0676R-A680

Fornitore: Bioss

Promo

Descrizione: Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.

Codice catalogo: BOSSBS-13376R-A680

UOM: 1 * 100 µl

Codice articolo fornitore: BS-13376R-A680

Codice articolo locale: BOSSBS-13376R-A680

Fornitore: Bioss

Promo

Descrizione: The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. Alternative splicing of the end of this gene results in three products of undetermined function.

Codice catalogo: BOSSBS-0242R-A647

UOM: 1 * 100 µl

Codice articolo fornitore: BS-0242R-A647

Codice articolo locale: BOSSBS-0242R-A647

Fornitore: Bioss

Promo

Descrizione: Has phospholipase and triglyceride lipase activities. Hydrolyses high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.

Codice catalogo: BOSSBS-2397R-A680

UOM: 1 * 100 µl

Codice articolo fornitore: BS-2397R-A680

Codice articolo locale: BOSSBS-2397R-A680

Fornitore: Bioss

Promo

Descrizione: Glucose Oxidase is a dimeric enzyme that binds to β-D-glucose and aids in its oxidation into D-glucono-1,5-lactone which then hydrolyzes to gluconic acid. Flavin adenine dinucleotide (FAD) is a cofactor to Glucose Oxidase that acts as the initial electron acceptor and is required for this oxidation to occur. Glucose Oxidase is a natural preservative found in honey, where it reduces atmospheric oxygen into hydrogen peroxide which acts as an antibacterial barrier. Glucose Oxidase is also commonly used in biosensors in which it conveys levels of glucose by keeping track of the number of electrons passed through the enzyme. In this application, Glucose Oxidase is connected to an electrode and the resulting charge is measured.

Codice catalogo: BOSSBS-13387R-A647

UOM: 1 * 100 µl

Codice articolo fornitore: BS-13387R-A647

Codice articolo locale: BOSSBS-13387R-A647

Fornitore: Bioss

Promo

Descrizione: Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.

Codice catalogo: BOSSBS-1769R-A488

UOM: 1 * 100 µl

Codice articolo fornitore: BS-1769R-A488

Codice articolo locale: BOSSBS-1769R-A488

Fornitore: Bioss

Promo