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R18 peptide

Fornitore: ENZO LIFE SCIENCES

BMLP2140001
ENZOBMLP2140001EA 234 EUR
ENZOBMLP2140001
R18 peptide
Proteine e Peptidi

14-3-3 inhibitor


The peptide sequence, PHCVPRDLSWLDLEANMCLP, named R18, was identified as an unphosphorylated peptide that binds to 14-3-3 proteins with high affinity (Kd=80 nM). It has been shown to bind to the same amphipathic groove on the surface of 14-3-3 as phosphorylated peptides. R18 can inhibit the formation of the 14-3-3-Raf-1 complex, reduce Raf-1 dependent transcriptional activity in cells and block the activation of ExoS by 14-3-3. It binds to all the 14-3-3 isoforms with equal affinities. This peptide is useful for competitive inhibition experiments. A biotinylated form is available (BML-P225), allowing detection using streptavidin.

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