Hai cercato: ENZO LIFE SCIENCES

Fornitore: ENZO LIFE SCIENCES

Descrizione: Anti-NAMPT Mouse Monoclonal Antibody [clone: P4D5AT]

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Codice catalogo: (ENZOALX8049140100)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX8049140100

Codice articolo locale: ENZOALX8049140100

Descrizione: DR5 is 55kDa member 10B of the TNF receptor superfamily (TNFRSF10B), also known as TRAIL-R2, TRICK2, KILLER, and CD262. It binds the cytotoxic ligand TRAIL and induces apoptosis. The DR5 receptor is broadly expressed on a variety of normal tissues and many tumors. DR5 expression has been reported to be upregulated in human cells by interferon-α, 2-methoxyestradiol, and paclitaxel, and downregulated by adenoviral E3 proteins.

UOM: 1 * 100 µG

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Codice catalogo: (ENZOALX805022C100)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX805022C100

Codice articolo locale: ENZOALX805022C100

Descrizione: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µG

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Codice catalogo: (ENZOALX804853C100)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX804853C100

Codice articolo locale: ENZOALX804853C100

Descrizione: Host: Mouse, Isotype: IgG2a lambda

UOM: 1 * 100 µG

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Codice catalogo: (ENZOALX804840C100)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX804840C100

Codice articolo locale: ENZOALX804840C100

Descrizione: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µG

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Fornitore: ENZO LIFE SCIENCES

Descrizione: Isotype matched controls are useful in flow cytometry to determine a gross estimate of non-specific binding that may be observed with a specific antibody of interest. In general, an isotype control should be of the same species and isotype as the antibody of interest, used at the same concentration, and conjugated to the same fluorophore. This reagent is an IgG1 isotype mouse monoclonal antibody (Clone # MOPC-21) conjugated to phycoerythrin (PE). It is intended for use as an isotype control antibody for flow cytometry.

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Codice catalogo: (ENZOADISAB500E)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ADISAB500E

Codice articolo locale: ENZOADISAB500E

Descrizione: The green fluorescent protein (GFP) is derived from the jellyfish Aequorea victoria, that fluoresces green when exposed to blue light. GFP is a frequently used reporter for gene expression in recombinant DNA and cell transfection systems. Detects a band of ~27kDa by western blot.

UOM: 1 * 100 µG

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Fornitore: ENZO LIFE SCIENCES

Descrizione: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor, which regulates the expression of many detoxification and antioxidant enzymes. Nrf2 can potentially play a significant role in adaptive responses to oxidative stress. Nrf2 belongs to the Cap N Collar subfamily of basic leucine zipper (CNC-bZIP) transcription factors. The NF-E2 related family comprises of Nrf1 (TCFII), Nrf2, and Nrf3 and these proteins heterodimerize with Maf proteins to bind to Maf recognition element (MARE). Under normal conditions, Nrf2 is inactive and localized in the cytoplasm through its association with Keap1. When cells are exposed to electrophiles or oxidative stress generating agents cytoplasm localization of Nrf2 is inactivated and Nrf2 translocates into the nucleus and binds to specific DNA sequence elements known as NF-E2 binding site, Maf recognition element (MARE), stress response element or anti-oxidant response element (ARE). Studies have investigated the role of Nrf2 in urinary bladder carcinogenesis, pulmonary fibrosis, and smoke-induced emphysema. A study reported Nrf2-mediated ARE transcription to be a likely target of preventative therapy in neurodegenerative disorders such as Huntington's disease.

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Fornitore: ENZO LIFE SCIENCES

Descrizione: PKA (Protein Kinase A), also known as cAMP-dependent protein kinase, phosphorylates serine or threonine residues in target protein in response to elevated levels of cAMP. Inactive PKA exists as a tetrameric protein composed of two regulatory (R) subunits and two catalytic (C) subunits. Activation occurs when two cAMP molecules bind to each R subunit which causes a conformational change that releases the active C subunits.

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Codice catalogo: (ENZOADIMSA102E)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ADIMSA102E

Codice articolo locale: ENZOADIMSA102E

Descrizione: The GST superfamily of enzymes play an important role in detoxification of xenobiotics by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione.

UOM: 1 * 100 µl

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Codice catalogo: (ENZOADISPA890D)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ADISPA890D

Codice articolo locale: ENZOADISPA890D

Descrizione: The mammalian PDI (Protein disulfide-isomerase) family encompasses several highly divergent proteins which are involved in the processing and maturation of secretory proteins in the endoplasmic reticulum by catalyzing the rearrangement of disulfide bonds.

UOM: 1 * 50 µG

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Fornitore: ENZO LIFE SCIENCES

Descrizione: HSFs (Heat Shock family of transcription factors), which consists of HSF 1-4, bind to highly conserved Heat shock elements (HSEs) in the promoter regions of heat shock genes, ultimately regulating the expression of Heat shock proteins (Hsps). On exposure to heat shock and other stresses, HSF1 localizes within seconds to discrete nuclear granules and on recovery from stress, HSF1 rapidly dissipates from the stress granules to a diffuse nucleoplasmic distribution.

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Codice catalogo: (ENZOADISPA895J)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ADISPA895J

Codice articolo locale: ENZOADISPA895J

Descrizione: Anti-HMOX1 Rabbit Polyclonal Antibody

UOM: 1 * 1 mg

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Fornitore: ENZO LIFE SCIENCES

Descrizione: The tetrapeptide KDEL, located at the carboxy-terminal sequences of luminal proteins, is a retrieval motif essential for the precise sorting of these proteins along the secretory pathway. KDEL proteins perform essential functions in the endoplasmic reticulum (ER) related to protein folding as well as assembly. The localization of chaperones and other soluble proteins to the ER is achieved by their continuous retrieval from post-ER compartments by the KDEL receptor (Erd2p), which is a membrane protein localized in the Golgi apparatus.

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Fornitore: ENZO LIFE SCIENCES

Descrizione: The Hsp70 family of heat shock proteins contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

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Codice catalogo: (ENZOADISPA815PEE)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ADISPA815PEE

Codice articolo locale: ENZOADISPA815PEE

Descrizione: The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

UOM: 1 * 100 µG

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